Ataxin 2 anticorps
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- Antigène Voir toutes Ataxin 2 (ATXN2) Anticorps
- Ataxin 2 (ATXN2)
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Ataxin 2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Immunogène
- ataxin 2
- Isotype
- IgG
- Top Product
- Discover our top product ATXN2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00657( Ataxin 2 Antibody) at dilution of 1:2000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- Ataxin 2 (ATXN2)
- Autre désignation
- Ataxin 2 (ATXN2 Produits)
- Synonymes
- anticorps ASL13, anticorps ATX2, anticorps SCA2, anticorps TNRC13, anticorps 9630045M23Rik, anticorps AW544490, anticorps Sca2, anticorps ATXN2, anticorps MGC115230, anticorps ataxin 2, anticorps ataxin 2 L homeolog, anticorps ATXN2, anticorps Atxn2, anticorps atxn2.L
- Sujet
- Synonyms:ataxin 2, ATX2, ATXN2, SCA2, TNRC13 Background:This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.
- Poids moléculaire
- 140-150 kDa
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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