APOBEC3C anticorps
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- Antigène Voir toutes APOBEC3C Anticorps
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp APOBEC3C est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogène
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
- Isotype
- IgG
- Top Product
- Discover our top product APOBEC3C Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Human peripheral blood leukocyte cells were subjected to SDS PAGE followed by western blot with FNab00494( APOBEC3C Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
- Autre désignation
- APOBEC3C (APOBEC3C Produits)
- Synonymes
- anticorps APOBEC3C, anticorps A3C, anticorps APOBEC1L, anticorps ARDC2, anticorps ARDC4, anticorps ARP5, anticorps PBI, anticorps bK150C2.3, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3C, anticorps apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C, anticorps APOBEC3C
- Sujet
- Synonyms:APOBEC1L, PBI Background:DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus(SIV), hepatitis B virus(HBV), herpes simplex virus 1(HHV-1) and Epstein-Barr virus(EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- Poids moléculaire
- 23 kDa
- ID gène
- 27350
- UniProt
- Q9NRW3
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