UBE2O anticorps
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- Antigène Voir toutes UBE2O Anticorps
- UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UBE2O est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Immunogène
- ubiquitin-conjugating enzyme E2O
- Isotype
- IgG
- Top Product
- Discover our top product UBE2O Anticorps primaire
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- Indications d'application
- WB : 1:200-1:2000
- Commentaires
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab09181(UBE2O antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
- Autre désignation
- UBE2O (UBE2O Produits)
- Synonymes
- anticorps e2-230k, anticorps E2-230K, anticorps 9630022H21, anticorps B230113M03Rik, anticorps mKIAA1734, anticorps RGD1310297, anticorps ubiquitin conjugating enzyme E2 O, anticorps ubiquitin-conjugating enzyme E2O, anticorps UBE2O, anticorps ube2o, anticorps Ube2o
- Sujet
- Synonyms:E2-230K, FLJ12878, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O Background:E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins(PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity(PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis(PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal(NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location(PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853).
- Poids moléculaire
- 18kDa
- ID gène
- 63893
- UniProt
- Q9C0C9
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