TNIP1 anticorps
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- Antigène Voir toutes TNIP1 Anticorps
- TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNIP1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Immunogène
- TNFAIP3 interacting protein 1
- Isotype
- IgG
- Top Product
- Discover our top product TNIP1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08831(TNFR2 antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))
- Autre désignation
- TNIP1 (TNIP1 Produits)
- Synonymes
- anticorps ABIN-1, anticorps NAF1, anticorps VAN, anticorps nip40-1, anticorps ABIN, anticorps ABIN1, anticorps AU018810, anticorps Naf1, anticorps Nef, anticorps im:7141452, anticorps naf1, anticorps zgc:158159, anticorps tnip1, anticorps MGC147597, anticorps TNFAIP3 interacting protein 1, anticorps TNFAIP3 interacting protein 1 S homeolog, anticorps TNFAIP3-interacting protein 1, anticorps TNIP1, anticorps Tnip1, anticorps tnip1, anticorps tnip1.S, anticorps LOC100078195
- Sujet
- Synonyms:KIAA0113, NAF1 Background:Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG, proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway, blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity, this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation, this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC(Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
- ID gène
- 10318
- UniProt
- Q15025
- Pathways
- Activation of Innate immune Response
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