ADA anticorps (AA 2-238)

N° du produit ABIN5708187

Détail du produit anti-ADA anticorps

Antigène: ADA (Adenosine Deaminase (ADA))

Épitope: AA 2-238

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogène: A recombinant mouse partial protein corresponding to amino acids A2-H238 was used as the immunogen for the ADA antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ADA antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the ADA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur ADA

Antigène: ADA (Adenosine Deaminase (ADA))

Autre désignation: ADA / Adenosine deaminase (ADA Produits)

Synonymes: anticorps ADA-like, anticorps xada, anticorps ADA, anticorps CG11994, anticorps Dmel\\CG11994, anticorps DrosADA, anticorps dADA, anticorps zgc:92028, anticorps adenosine deaminase, anticorps adenosine deaminase S homeolog, anticorps Adenosine deaminase, anticorps ADA, anticorps Ada, anticorps ada.S, anticorps ada

Sujet: Adenosine Deaminase (also known as Adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism. Primarily, ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins. Adenosine deaminase deficiency leads to pulmonary fibrosis, suggesting that chronic exposure to high levels of adenosine can exacerbate inflammation responses rather than suppressing them. It has also been recognized that adenosine deaminase protein and activity is upregulated in mouse hearts that overexpress HIF-1 alpha, which in part explains the attenuated levels of adenosine in HIF-1 alpha expressing hearts during ischemic stress.

UniProt: P03958

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Ribonucleoside Biosynthetic Process