ULK1 anticorps (pSer757)
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- Antigène Voir toutes ULK1 Anticorps
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
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Épitope
- pSer757
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ULK1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- TVGSP
- Réactivité croisée
- Humain
- Attributs du produit
- Phosphorylated Antibodies
- Immunogène
- A synthetic phosphorylated peptide around S757 of human Phospho-ULK1-S757 (NP_003556.1).
- Isotype
- IgG
- Top Product
- Discover our top product ULK1 Anticorps primaire
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- Indications d'application
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- Autre désignation
- ULk1 (ULK1 Produits)
- Synonymes
- anticorps ATG1, anticorps ATG1A, anticorps UNC51, anticorps Unc51.1, anticorps hATG1, anticorps si:dkey-11o18.7, anticorps ulk1, anticorps ULK1, anticorps AU041434, anticorps mKIAA0722, anticorps zgc:195008, anticorps unc-51 like autophagy activating kinase 1, anticorps unc-51 like kinase 1, anticorps unc-51 like autophagy activating kinase 1a, anticorps ULK1, anticorps Ulk1, anticorps ulk1b, anticorps ulk1a
- Sujet
- Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.,ULK1,ATG1,ATG1A,UNC51,Unc51.1,hATG1,ULk1,Signal Transduction,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Mitochondrial metabolism,Mitophagy fission and fusion,Neuroscience,Cardiovascular,Heart,Regulator of mTOR complex function,Regulators,Protein phosphorylation,ULk1
- Poids moléculaire
- 150 kDa
- ID gène
- 8408
- UniProt
- O75385
- Pathways
- Regulation of Cell Size, Autophagy
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