ATR anticorps (AA 400-650)

N° du produit ABIN6137357

Détail du produit anti-ATR anticorps

Antigène: ATR (ATR serine/threonine kinase (ATR))

Épitope: AA 400-650

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Western Blotting (WB)

Séquence: LKMESMEIIE EIQCQTQQEN LSSNSDGISP KRRRLSSSLN PSKRAPKQTE EIKHVDMNQK SILWSALKQK AESLQISLEY SGLKNPVIEM LEGIAVVLQL TALCTVHCSH QNMNCRTFKD CQHKSKKKPS VVITWMSLDF YTKVLKSCRS LLESVQKLDL EATIDKVVKI YDALIYMQVN SSFEDHILED LCGMLSLPWI YSHSDDGCLK LTTFAANLLT LSCRISDSYS PQAQSRCVFL LTLFPRRIFL E

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR (ATR Produits)

Synonymes: anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr

Sujet: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.,ATR,FCTCS,FRP1,MEC1,SCKL,SCKL1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,ATR

Poids moléculaire: 294 kDa/297 kDa/301 kDa

ID gène: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus