Calmodulin 2 anticorps (AA 1-149)

N° du produit ABIN6137872

Détail du produit anti-Calmodulin 2 anticorps

Antigène: Calmodulin 2 (Calm2) (Calmodulin 2 (phosphorylase Kinase, Delta) (Calm2))

Épitope: AA 1-149

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calmodulin 2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Calmodulin 2

Antigène: Calmodulin 2 (Calm2) (Calmodulin 2 (phosphorylase Kinase, Delta) (Calm2))

Autre désignation: CALM2 (Calm2 Produits)

Synonymes: anticorps CAMII, anticorps PHKD, anticorps PHKD2, anticorps 1500001E21Rik, anticorps AL024017, anticorps calm1, anticorps camii, anticorps phkd, anticorps phkd2, anticorps ATCAL5, anticorps CALMODULIN 2, anticorps T3K9.12, anticorps T3K9_12, anticorps calmodulin 2, anticorps CALM2, anticorps calmodulin 2, anticorps calmodulin 2 (phosphorylase kinase, delta) L homeolog, anticorps calmodulin-like, anticorps CALM2, anticorps Calm2, anticorps calm2.L, anticorps CAM2, anticorps CALM

Sujet: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.,CALM2,CAMII,LQT15,PHKD,PHKD2,caM,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,CALM2

Poids moléculaire: 17 kDa

ID gène: 805

UniProt: P62158

Pathways: Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cellular Glucan Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Phototransduction, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals, BCR Signaling