CFHR5 anticorps (AA 450-569)

N° du produit ABIN6138459

Détail du produit anti-CFHR5 anticorps

Antigène: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Épitope: AA 450-569

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CFHR5 est non-conjugé

Application: Western Blotting (WB)

Séquence: GPPPSINNGD TTSFPLSVYP PGSTVTYRCQ SFYKLQGSVT VTCRNKQWSE PPRCLDPCVV SEENMNKNNI QLKWRNDGKL YAKTGDAVEF QCKFPHKAMI SSPPFRAICQ EGKFEYPICE

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 450-569 of human CFHR5 (NP_110414.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CFHR5

Antigène: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Autre désignation: CFHR5 (CFHR5 Produits)

Synonymes: anticorps CFHL5, anticorps CFHR5D, anticorps FHR-5, anticorps FHR5, anticorps complement factor H related 5, anticorps CFHR5

Sujet: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).,CFHR5,CFHL5,CFHR5D,FHR-5,FHR5,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CFHR5

Poids moléculaire: 64 kDa

ID gène: 81494

UniProt: Q9BXR6