Claudin 16 anticorps (AA 50-150)

N° du produit ABIN6138679

Détail du produit anti-Claudin 16 anticorps

Antigène: Claudin 16 (CLDN16)

Épitope: AA 50-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 16 est non-conjugé

Application: Western Blotting (WB)

Séquence: HLSGARAGVC PCCHPDGLLA TMRDLLQYIA CFFAFFSAGF LIVATWTDCW MVNADDSLEV STKCRGLWWE CVTNAFDGIR TCDEYDSILA EHPLKLVVTR A

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CLDN16 (NP_006571.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Claudin 16

Antigène: Claudin 16 (CLDN16)

Autre désignation: CLDN16 (CLDN16 Produits)

Synonymes: anticorps CLDN16, anticorps HOMG3, anticorps PCLN1, anticorps claudin-16, anticorps Pcln1, anticorps claudin 16, anticorps CLDN16, anticorps Cldn16

Sujet: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.,CLDN16,HOMG3,PCLN1,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Tight Junctions,Cytoskeleton,CLDN16

Poids moléculaire: 33 kDa

ID gène: 10686

UniProt: Q9Y5I7

Pathways: Hepatitis C