COCH anticorps (AA 20-260)

N° du produit ABIN6138819

Détail du produit anti-COCH anticorps

Antigène: COCH (Cochlin (COCH))

Épitope: AA 20-260

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COCH est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: GPAGSEGAAP IAITCFTRGL DIRKEKADVL CPGGCPLEEF SVYGNIVYAS VSSICGAAVH RGVISNSGGP VRVYSLPGRE NYSSVDANGI QSQMLSRWSA SFTVTKGKSS TQEATGQAVS TAHPPTGKRL KKTPEKKTGN KDCKADIAFL IDGSFNIGQR RFNLQKNFVG KVALMLGIGT EGPHVGLVQA SEHPKIEFYL KNFTSAKDVL FAIKEVGFRG GNSNTGKALK HTAQKFFTVD A

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).

Isotype: IgG

Information d'application

Indications d'application: IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur COCH

Antigène: COCH (Cochlin (COCH))

Autre désignation: COCH (COCH Produits)

Synonymes: anticorps AW122937, anticorps Coch-5B2, anticorps D12H14S564E, anticorps COCH-5B2, anticorps COCH5B2, anticorps DFNA9, anticorps cochlin, anticorps Coch, anticorps COCH

Sujet: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.,COCH,COCH-5B2,COCH5B2,DFNA9,cochlin,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Neuroscience,COCH

Poids moléculaire: 53 kDa/59 kDa

ID gène: 1690

UniProt: O43405

Pathways: Sensory Perception of Sound