CD35 anticorps (AA 420-550)

N° du produit ABIN6138990

Détail du produit anti-CD35 anticorps

Antigène: CD35 (CR1) (Complement Component Receptor 1 (CD35) (CR1))

Épitope: AA 420-550

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD35 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: FCPSPPVIPN GRHTGKPLEV FPFGKTVNYT CDPHPDRGTS FDLIGESTIR CTSDPQGNGV WSSPAPRCGI LGHCQAPDHF LFAKLKTQTN ASDFPIGTSL KYECRPEYYG RPFSITCLDN LVWSSPKDVC K

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 420-550 of human CD35/CD35/CR1 (NP_000642.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CD35

Antigène: CD35 (CR1) (Complement Component Receptor 1 (CD35) (CR1))

Autre désignation: CR1 (CR1 Produits)

Sujet: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.,CR1,C3BR,C4BR,CD35,KN,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,CR1

Poids moléculaire: 223 kDa

ID gène: 1378

UniProt: P17927

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Endopeptidase Activity