ERCC1 anticorps (AA 1-323)

N° du produit ABIN6140263

Détail du produit anti-ERCC1 anticorps

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Épitope: AA 1-323

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS IIVSPRQRGN PVLKFVRNVP WEFGDVIPDY VLGQSTCALF LSLRYHNLHP DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KVRALGKNPR SWGKERAPNK HNLRPQSFKV KKEPKTRHSG FRL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ERCC1 (NP_973730.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1 (ERCC1 Produits)

Synonymes: anticorps COFS4, anticorps RAD10, anticorps UV20, anticorps Ercc-1, anticorps ercc1, anticorps T12H1.18, anticorps T12H1_18, anticorps UV REPAIR DEFICIENT 7, anticorps UVR7, anticorps ERCC excision repair 1, endonuclease non-catalytic subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 1, anticorps DNA excision repair protein ERCC-1, anticorps nucleotide repair protein, anticorps excision repair cross-complementation group 1 L homeolog, anticorps excision repair cross-complementation group 1, anticorps ERCC1, anticorps Ercc1, anticorps CC1G_04546, anticorps CpipJ_CPIJ013903, anticorps PITG_13719, anticorps ercc1, anticorps ercc1.L

Sujet: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.,ERCC1,COFS4,RAD10,UV20,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor biomarkers,ERCC1

Poids moléculaire: 25 kDa/29 kDa/32 kDa/35 kDa

ID gène: 2067

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response