EXOSC7 anticorps (AA 1-291)

N° du produit ABIN6140380

Détail du produit anti-EXOSC7 anticorps

Antigène: EXOSC7 (Exosome Component 7 (EXOSC7))

Épitope: AA 1-291

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC7 est non-conjugé

Application: Western Blotting (WB)

Séquence: MASVTLSEAE KVYIVHGVQE DLRVDGRGCE DYRCVEVETD VVSNTSGSAR VKLGHTDILV GVKAEMGTPK LEKPNEGYLE FFVDCSASAT PEFEGRGGDD LGTEIANTLY RIFNNKSSVD LKTLCISPRE HCWVLYVDVL LLECGGNLFD AISIAVKAAL FNTRIPRVRV LEDEEGSKDI ELSDDPYDCI RLSVENVPCI VTLCKIGYRH VVDATLQEEA CSLASLLVSV TSKGVVTCMR KVGKGSLDPE SIFEMMETGK RVGKVLHASL QSVVHKEESL GPKRQKVGFL G

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human EXOSC7 (NP_055819.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EXOSC7

Antigène: EXOSC7 (Exosome Component 7 (EXOSC7))

Autre désignation: EXOSC7 (EXOSC7 Produits)

Synonymes: anticorps EXOSC7, anticorps zgc:110717, anticorps EAP1, anticorps RRP42, anticorps Rrp42p, anticorps hRrp42p, anticorps p8, anticorps 2610002K22Rik, anticorps AV212732, anticorps mKIAA0116, anticorps exosome component 7, anticorps exosome component 7 S homeolog, anticorps exosc7, anticorps EXOSC7, anticorps exosc7.S, anticorps Exosc7

Sujet: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9 is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.,EXOSC7,EAP1,RRP42,Rrp42p,hRrp42p,p8,Epigenetics & Nuclear Signaling,EXOSC7

Poids moléculaire: 31 kDa

ID gène: 23016

UniProt: Q15024