FAM208A anticorps (AA 700-1000)
FAM208A
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
1 image
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- Antigène
- FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
- Épitope
- AA 700-1000
- Reactivité
- Humain
- Hôte
- Lapin
- Clonalité
- Polyclonal
- Application
- Western Blotting (WB)
- Séquence
- DTEDMRSKTV LKRKLEDLPE NMRKLAKTSN LSENCHLYEE SPQPIGSLGH DADLRRQQQD TCNSGIADIH RLFNWLSETL ANARHSDASL TDTVNKALGL STDDAYEELR QKHEYELNST PDKKDYEQPT CAKVENAQFK GTQSLLLEVD ATSKYSVAIS TSEVGTDHKL HLKEDPNLIS VNNFEDCSLC PSVPIEHGFR RQQSKSNNVE ETEIHWKLIP ITGGNARSPE DQLGKHGEKQ TPGMKSPEEQ LVCVPPQEAF PNDPRVINRQ RSSDYQFPSS PFTDTLKGTT EDDVLTGQVE E
- Réactivité croisée
- Humain
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1).
- Isotype
- IgG
-
- Indications d'application
- WB,1:500 - 1:2000
- Commentaires
-
HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Antigène
- FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))
- Autre désignation
- FAM208A
- Synonymes
- anticorps c3orf63-a, anticorps c3orf63.1, anticorps fam208a, anticorps rap140, anticorps se89-1, anticorps C3orf63, anticorps RAP140, anticorps family with sequence similarity 208 member A L homeolog, anticorps family with sequence similarity 208 member A, anticorps fam208a.L, anticorps FAM208A
- Sujet
- Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development (By similarity. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity. Plays an important role in maintaining epiblast fitness or potency (By similarity.,FAM208A,C3orf63,RAP140,TASOR,se89-1,Epigenetics & Nuclear Signaling,RNA Binding,FAM208A
- Poids moléculaire
- 139 kDa/170 kDa/182 kDa/189 kDa
- ID gène
- 23272
- UniProt
- Q9UK61
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