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FURIN anticorps (AA 120-370)

FURIN Reactivité: Humain WB, IHC, IP, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6140815
  • Antigène Voir toutes FURIN Anticorps
    FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
    Épitope
    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 120-370
    Reactivité
    • 38
    • 36
    • 16
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 52
    • 3
    • 3
    Lapin
    Clonalité
    • 45
    • 13
    Polyclonal
    Conjugué
    • 25
    • 10
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FURIN est non-conjugé
    Application
    • 27
    • 18
    • 16
    • 13
    • 13
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Séquence
    QQWYLSGVTQ RDLNVKAAWA QGYTGHGIVV SILDDGIEKN HPDLAGNYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA GEVAAVANNG VCGVGVAYNA RIGGVRMLDG EVTDAVEARS LGLNPNHIHI YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE HDSCNCDGYT NSIYTLSISS ATQFGNVPWY SEACSSTLAT TYSSGNQNEK QIVTTDLRQK CTESHTGTSA S
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 120-370 of human Furin (NP_002560.1).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
    Autre désignation
    FURIN (FURIN Produits)
    Synonymes
    anticorps FURIN, anticorps furin, anticorps si:dkey-281a24.5, anticorps FUR, anticorps LOC100220259, anticorps PACE, anticorps spc1, anticorps xfurin, anticorps MGC82710, anticorps PCSK3, anticorps SPC1, anticorps 9130404I01Rik, anticorps Fur, anticorps Pcsk3, anticorps Pace, anticorps furin, paired basic amino acid cleaving enzyme, anticorps furin (paired basic amino acid cleaving enzyme) a, anticorps furin (paired basic amino acid cleaving enzyme) b, anticorps furin, paired basic amino acid cleaving enzyme L homeolog, anticorps furin (paired basic amino acid cleaving enzyme), anticorps FURIN, anticorps furina, anticorps furinb, anticorps furin, anticorps furin.L, anticorps Furin
    Sujet
    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.,FURIN,FUR,PACE,PCSK3,SPC1,furin,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Ubiquitin,Notch Signaling Pathway,Endocrine & Metabolism,FURIN
    Poids moléculaire
    86 kDa
    ID gène
    5045
    UniProt
    P09958
    Pathways
    Signalisation Notch, Neurotrophin Signaling Pathway
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