GCN1L1 anticorps (AA 2462-2671)
-
- Antigène Voir toutes GCN1L1 Anticorps
- GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))
-
Épitope
- AA 2462-2671
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp GCN1L1 est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- LSAVLQQCLL ADVSGIDWMV RHGRSLALSV AVNVAPGRLC AGRYSSDVQE MILSSATADR IPIAVSGVRG MGFLMRHHIE TGGGQLPAKL SSLFVKCLQN PSSDIRLVAE KMIWWANKDP LPPLDPQAIK PILKALLDNT KDKNTVVRAY SDQAIVNLLK MRQGEEVFQS LSKILDVASL EVLNEVNRRS LKKLASQADS TEQVDDTILT
- Réactivité croisée
- Humain
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 2462-2671 of human GCN1L1 (NP_006827.1).
- Isotype
- IgG
-
-
- Indications d'application
- WB,1:500 - 1:2000
- Commentaires
-
HIGH QUALITY
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Antigène
- GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))
- Autre désignation
- GCN1L1 (GCN1L1 Produits)
- Synonymes
- anticorps GCN1, anticorps GCN1L, anticorps PRIC295, anticorps 4932409G22, anticorps AL022764, anticorps G431004K08Rik, anticorps mKIAA0219, anticorps GCN1, eIF2 alpha kinase activator homolog, anticorps GCN1 general control of amino-acid synthesis 1-like 1 (yeast), anticorps GCN1 eIF2 alpha kinase activator-like 1, anticorps GCN1, anticorps Gcn1l1
- Sujet
- Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.,GCN1,GCN1L,GCN1L1,PRIC295,Epigenetics & Nuclear Signaling,GCN1L1
- Poids moléculaire
- 292 kDa
- ID gène
- 10985
- UniProt
- Q92616
-