HIF1AN anticorps (AA 1-349)
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- Antigène Voir toutes HIF1AN Anticorps
- HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
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Épitope
- AA 1-349
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HIF1AN est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- Séquence
- MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human HIF1AN/FIH1 (NP_060372.2).
- Isotype
- IgG
- Top Product
- Discover our top product HIF1AN Anticorps primaire
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- Indications d'application
- WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
- Commentaires
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
- Autre désignation
- HIF1AN (HIF1AN Produits)
- Synonymes
- anticorps FIH1, anticorps 2310046M24Rik, anticorps A830014H24Rik, anticorps cb728, anticorps id:ibd5139, anticorps hypoxia inducible factor 1 alpha subunit inhibitor, anticorps hypoxia-inducible factor 1, alpha subunit inhibitor, anticorps hypoxia inducible factor 1, alpha subunit inhibitor, anticorps hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog, anticorps HIF1AN, anticorps Hif1an, anticorps hif1an, anticorps hif1an.S
- Sujet
- Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.,HIF1AN,FIH1,Epigenetics & Nuclear Signaling,Cancer,Invasion and Metastasis,Cardiovascular,Hypoxia,HIF,HIF1AN
- Poids moléculaire
- 40 kDa
- ID gène
- 55662
- UniProt
- Q9NWT6
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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