HSPA6 anticorps (AA 474-643)

N° du produit ABIN6142046

Détail du produit anti-HSPA6 anticorps

Antigène: HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6))

Épitope: AA 474-643

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPA6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PQIEVTFDID ANGILSVTAT DRSTGKANKI TITNDKGRLS KEEVERMVHE AEQYKAEDEA QRDRVAAKNS LEAHVFHVKG SLQEESLRDK IPEEDRRKMQ DKCREVLAWL EHNQLAEKEE YEHQKRELEQ ICRPIFSRLY GGPGVPGGSS CGTQARQGDP STGPIIEEVD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 474-643 of human HSPA6 (NP_002146.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HSPA6

Antigène: HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6))

Autre désignation: HSPA6 (HSPA6 Produits)

Synonymes: anticorps HSPA6, anticorps HSP70B', anticorps heat shock protein family A (Hsp70) member 6, anticorps HSPA6

Sujet: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.,HSPA6,HSP70B,Cancer,Tumor biomarkers,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,HSPA6

Poids moléculaire: 71 kDa

ID gène: 3310

UniProt: P17066