ICOSLG anticorps (AA 19-256)

N° du produit ABIN6142131

Détail du produit anti-ICOSLG anticorps

Antigène: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Épitope: AA 19-256

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ICOSLG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAAT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 19-256 of human ICOSL (NP_056074.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ICOSLG

Antigène: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Autre désignation: ICOSLG (ICOSLG Produits)

Synonymes: anticorps ICOSLG, anticorps AU044799, anticorps B7-H2, anticorps B7RP-1, anticorps B7h, anticorps BG071784, anticorps GI50, anticorps GL50, anticorps GL50-B, anticorps ICOS-L, anticorps Icoslg, anticorps LICOS, anticorps Ly115l, anticorps mKIAA0653, anticorps B7H2, anticorps B7RP1, anticorps CD275, anticorps ICOSL, anticorps Icosl, anticorps RGD1562791, anticorps inducible T-cell costimulator ligand, anticorps icos ligand, anticorps inducible T-cell co-stimulator ligand, anticorps ICOSLG, anticorps Icosl, anticorps Icoslg

Sujet: Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.,ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,Immunology & Inflammation,CD markers,ICOSLG

Poids moléculaire: 20 kDa/33 kDa/34 kDa

ID gène: 23308

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation