This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.,KDM5A,RBBP-2,RBBP2,RBP2,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Demethylation,Transcription Factors,Nuclear Receptor Signaling,Cell Biology & Developmental Biology,Notch Signaling Pathway,KDM5A