LAMB2 anticorps (AA 1579-1798)

N° du produit ABIN6143070

Détail du produit anti-LAMB2 anticorps

Antigène: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Épitope: AA 1579-1798

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMB2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: DVRRAEQLLQ DARRARSWAE DEKQKAETVQ AALEEAQRAQ GIAQGAIRGA VADTRDTEQT LYQVQERMAG AERALSSAGE RARQLDALLE ALKLKRAGNS LAASTAEETA GSAQGRAQEA EQLLRGPLGD QYQTVKALAE RKAQGVLAAQ ARAEQLRDEA RDLLQAAQDK LQRLQELEGT YEENERALES KAAQLDGLEA RMRSVLQAIN LQVQIYNTCQ

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1579-1798 of human LAMB2 (NP_002283.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LAMB2

Antigène: LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))

Autre désignation: LAMB2 (LAMB2 Produits)

Synonymes: anticorps LAMS, anticorps NPHS5, anticorps AW211941, anticorps Lamb-2, anticorps Lams, anticorps SLAM, anticorps lamb1, anticorps lams, anticorps LAMC1, anticorps laminin, anticorps laminin subunit beta 2, anticorps laminin, beta 2, anticorps laminin subunit beta 2 L homeolog, anticorps laminin, beta 2 (laminin S), anticorps LAMB2, anticorps Lamb2, anticorps lamb2.L

Sujet: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma . Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form.,LAMB2,LAMS,NPHS5,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Intermediate Filaments,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,LAMB2

Poids moléculaire: 195 kDa

ID gène: 3913

UniProt: P55268

Pathways: Skeletal Muscle Fiber Development