anticorps AW107687, anticorps LAMAN, anticorps Laman, anticorps Manb, anticorps MANB, anticorps mannosidase alpha class 2B member 1, anticorps mannosidase, alpha, class 2B, member 1, anticorps mannosidase 2, alpha B1, anticorps MAN2B1, anticorps man2b1, anticorps Man2b1
Sujet
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,MAN2B1,LAMAN,MANB,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,MAN2B1