Human recombinant p40 and p19 with elastin linker. The HLT2736 clone recognizes Human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a Capture antibody in ELISA.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C.
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The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF