MLKL anticorps

N° du produit ABIN6143883

Détail du produit anti-MLKL anticorps

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant protein of mouse MLKL

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-MLKL (ABIN6143883)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." dans: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

Zhang, Lyu, Liu, Lv, Chang, Rubinsky: "Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver." dans: Biochemical and biophysical research communications, Vol. 500, Issue 3, pp. 665-670, (2018) (PubMed).

Huang, Zheng, Wang, Chen, He, Zhang, Xu, Zhao, Shi, Wang, Zhu, Han: "The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process." dans: Molecular and cellular biology, Vol. 37, Issue 5, (2017) (PubMed).

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL (MLKL Produits)

Synonymes: anticorps MLKL, anticorps 9130019I15Rik, anticorps mixed lineage kinase domain like pseudokinase, anticorps mixed lineage kinase domain-like, anticorps MLKL, anticorps mlkl, anticorps Mlkl

Sujet: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.,MLKL,hMLKL,Signal Transduction,Kinase,MLKL

Poids moléculaire: 53 kDa/54 kDa

ID gène: 74568

UniProt: Q9D2Y4