MUC1 anticorps (AA 1182-1255)

N° du produit ABIN6144194

Détail du produit anti-MUC1 anticorps

Antigène: MUC1 (Mucin 1 (MUC1))

Épitope: AA 1182-1255

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUC1 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1182-1255aa of human MUC1 (NP_002708.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:3000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MUC1

Antigène: MUC1 (Mucin 1 (MUC1))

Autre désignation: MUC1 (MUC1 Produits)

Synonymes: anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1

Sujet: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.,ADMCKD,ADMCKD1,CA 15-3,CD227,EMA,H23AG,KL-6,MAM6,MCD,MCKD,MCKD1,MUC-1,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,MUC1,CA15-3,mucin-1,Cancer,Tumor immunology,Tumor-associated antigens,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Immunology & Inflammation,CD markers,MUC1

Poids moléculaire: 10-29 kDa/103 kDa/121-122 kDa

ID gène: 4582

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling