NCOA2 anticorps (AA 550-820)

N° du produit ABIN6144413

Détail du produit anti-NCOA2 anticorps

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Épitope: AA 550-820

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: SSLASPDLKM GNLQNSPVNM NPPPLSKMGS LDSKDCFGLY GEPSEGTTGQ AESSCHPGEQ KETNDPNLPP AVSSERADGQ SRLHDSKGQT KLLQLLTTKS DQMEPSPLAS SLSDTNKDST GSLPGSGSTH GTSLKEKHKI LHRLLQDSSS PVDLAKLTAE ATGKDLSQES SSTAPGSEVT IKQEPVSPKK KENALLRYLL DKDDTKDIGL PEITPKLERL DSKTDPASNT KLIAMKTEKE EMSFEPGDQP GSELDNLEEI LDDLQNSQLP Q

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 550-820 of human NCOA2 (NP_006531.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NCOA2

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Autre désignation: NCOA2 (NCOA2 Produits)

Synonymes: anticorps GRIP1, anticorps KAT13C, anticorps NCoA-2, anticorps SRC2, anticorps TIF2, anticorps bHLHe75, anticorps 9530095N19, anticorps D1Ertd433e, anticorps GRIP-1, anticorps Grip1, anticorps SRC-2, anticorps TIF-2, anticorps tif2, anticorps wu:fc41a10, anticorps wu:fe26a11, anticorps Tif2, anticorps NCOA2, anticorps XTIF2, anticorps bhlhe75, anticorps grip1, anticorps kat13c, anticorps src2, anticorps ncoa2-A, anticorps nuclear receptor coactivator 2, anticorps nuclear receptor coactivator 2 S homeolog, anticorps NCOA2, anticorps Ncoa2, anticorps ncoa2, anticorps LOC100089041, anticorps ncoa2.S

Sujet: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.,NCOA2,GRIP1,KAT13C,NCoA-2,SRC2,TIF2,bHLHe75,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Obesity,NCOA2

Poids moléculaire: 159 kDa

ID gène: 10499

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling