Merlin anticorps (AA 477-576)

N° du produit ABIN6144548

Détail du produit anti-Merlin anticorps

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Épitope: AA 477-576

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Merlin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Séquence: TKPTYPPMNP IPAPLPPDIP SFNLIGDSLS FDFKDTDMKR LSMEIEKEKV EYMEKSKHLQ EQLNELKTEI EALKLKERET ALDILHNENS DRGGSSKHNT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Merlin

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Autre désignation: NF2 (NF2 Produits)

Synonymes: anticorps ACN, anticorps BANF, anticorps SCH, anticorps NF2, anticorps merlin, anticorps zgc:194620, anticorps zgc:194631, anticorps NF2a, anticorps nf2, anticorps neurofibromin 2, anticorps neurofibromin 2a (merlin), anticorps neurofibromin 2b (merlin), anticorps neurofibromin 2 (merlin) S homeolog, anticorps NF2, anticorps Nf2, anticorps nf2a, anticorps nf2b, anticorps nf2.S

Sujet: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.,NF2,ACN,BANF,SCH,merlin,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Hippo Signaling Pathway,Neuroscience,NF2

Poids moléculaire: 19-30 kDa/59-72 kDa

ID gène: 4771

UniProt: P35240

Pathways: Cell-Cell Junction Organization