PDHX anticorps (AA 1-300)

N° du produit ABIN6145384

Détail du produit anti-PDHX anticorps

Antigène: PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDHX est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Séquence: MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PDHX (NP_003468.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PDHX

Antigène: PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))

Autre désignation: PDHX (PDHX Produits)

Synonymes: anticorps DLDBP, anticorps E3BP, anticorps OPDX, anticorps PDX1, anticorps proX, anticorps AI481367, anticorps E3bp, anticorps Pdx1, anticorps Ac1164, anticorps zgc:66110, anticorps zgc:85977, anticorps MGC86218, anticorps PDHX, anticorps DDBDRAFT_0168431, anticorps DDBDRAFT_0230192, anticorps DDB_0168431, anticorps DDB_0230192, anticorps pyruvate dehydrogenase complex component X, anticorps pyruvate dehydrogenase complex, component X, anticorps pyruvate dehydrogenase complex component X L homeolog, anticorps E3-binding protein, anticorps PDHX, anticorps Pdhx, anticorps pdhx, anticorps pdhx.L, anticorps pdhX

Sujet: The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit, also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,PDHX,DLDBP,E3BP,OPDX,PDX1,proX,Cancer,Signal Transduction,Endocrine & Metabolism,Carbohydrate metabolism,Warburg Effect,PDHX

Poids moléculaire: 29 kDa/51 kDa/54 kDa

ID gène: 8050

UniProt: O00330