PHF19 anticorps (AA 1-207)

N° du produit ABIN6145539

Détail du produit anti-PHF19 anticorps

Antigène: PHF19 (PHD Finger Protein 19 (PHF19))

Épitope: AA 1-207

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHF19 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MENRALDPGT RDSYGATSHL PNKGALAKVK NNFKDLMSKL TEGQYVLCRW TDGLYYLGKI KRVSSSKQSC LVTFEDNSKY WVLWKDIQHA GVPGEEPKCN ICLGKTSGPL NEILICGKCG LGYHQQCHIP IAGSADQPLL TPWFCRRCIF ALAVRVSLPS SPVPASPASS SGADQRLPSQ SLSSKQKGHT WALETDSASA TVLGQDL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human PHF19 (NP_001009936.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PHF19

Antigène: PHF19 (PHD Finger Protein 19 (PHF19))

Autre désignation: PHF19 (PHF19 Produits)

Synonymes: anticorps si:dkeyp-51b7.1, anticorps pcl3, anticorps MGC147603, anticorps MTF2L1, anticorps PCL3, anticorps TDRD19B, anticorps 3110009G19Rik, anticorps 3321402G02Rik, anticorps PHD finger protein 19, anticorps Phf19, anticorps PHF19, anticorps phf19

Sujet: Polycomb group (PcG protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.,PHF19,MTF2L1,PCL3,TDRD19B,Epigenetics & Nuclear Signaling,Transcription Factors,PHF19

Poids moléculaire: 14 kDa/22 kDa/65 kDa

ID gène: 26147

UniProt: Q5T6S3

Pathways: Stem Cell Maintenance