RAD17 anticorps (AA 391-670)

N° du produit ABIN6146626

Détail du produit anti-RAD17 anticorps

Antigène: RAD17

Épitope: AA 391-670

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD17 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Séquence: KILYCKRASL TELDSPRLPS HLSEYERDTL LVEPEEVVEM SHMPGDLFNL YLHQNYIDFF MEIDDIVRAS EFLSFADILS GDWNTRSLLR EYSTSIATRG VMHSNKARGY AHCQGGGSSF RPLHKPQWFL INKKYRENCL AAKALFPDFC LPALCLQTQL LPYLALLTIP MRNQAQISFI QDIGRLPLKR HFGRLKMEAL TDREHGMIDP DSGDEAQLNG GHSAEESLGE PTQATVPETW SLPLSQNSAS ELPASQPQPF SAQGDMEENI IIEDYESDGT

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 391-670 of human RAD17 (NP_002864.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RAD17

Antigène: RAD17

Autre désignation: RAD17 (RAD17 Produits)

Synonymes: anticorps zgc:91969, anticorps RAD17, anticorps K2A18.21, anticorps K2A18_21, anticorps RADIATION SENSITIVE 17, anticorps CCYC, anticorps HRAD17, anticorps R24L, anticorps RAD17SP, anticorps RAD24, anticorps 9430035O09Rik, anticorps MmRad24, anticorps RAD17 checkpoint clamp loader component, anticorps Rad17p, anticorps RADIATION SENSITIVE 17, anticorps RAD17, anticorps rad17, anticorps ATRAD17, anticorps Rad17

Sujet: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.,RAD17,CCYC,HRAD17,R24L,RAD17SP,RAD24,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RAD17

Poids moléculaire: 57 kDa/66 kDa/75 kDa/77 kDa

ID gène: 5884

UniProt: O75943