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RIPK1 anticorps (AA 170-440)

RIPK1 Reactivité: Humain WB, IHC, IP, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6146959
  • Antigène Voir toutes RIPK1 Anticorps
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Épitope
    • 16
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-440
    Reactivité
    • 84
    • 40
    • 28
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 80
    • 10
    Lapin
    Clonalité
    • 72
    • 18
    Polyclonal
    Conjugué
    • 34
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RIPK1 est non-conjugé
    Application
    • 59
    • 33
    • 18
    • 15
    • 13
    • 13
    • 10
    • 10
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Séquence
    NEEHNELREV DGTAKKNGGT LYYMAPEHLN DVNAKPTEKS DVYSFAVVLW AIFANKEPYE NAICEQQLIM CIKSGNRPDV DDITEYCPRE IISLMKLCWE ANPEARPTFP GIEEKFRPFY LSQLEESVEE DVKSLKKEYS NENAVVKRMQ SLQLDCVAVP SSRSNSATEQ PGSLHSSQGL GMGPVEESWF APSLEHPQEE NEPSLQSKLQ DEANYHLYGS RMDRQTKQQP RQNVAYNREE ERRRRVSHDP FAQQRPYENF QNTEGKGTAY S
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 170-440 of human RIPK1/RIP (NP_003795.2).
    Isotype
    IgG
    Top Product
    Discover our top product RIPK1 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Autre désignation
    RIPK1 (RIPK1 Produits)
    Synonymes
    anticorps RIP, anticorps RIP1, anticorps D330015H01Rik, anticorps Rinp, anticorps Rip1, anticorps rip1, anticorps ripk1, anticorps xRIP1beta, anticorps xrip1, anticorps receptor interacting serine/threonine kinase 1, anticorps receptor (TNFRSF)-interacting serine-threonine kinase 1, anticorps receptor interacting serine/threonine kinase 1 L homeolog, anticorps RIPK1, anticorps Ripk1, anticorps ripk1.L
    Sujet
    3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.,RIP,RIP-1,RIP1,RIPK1,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Death receptors & ligands,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,RIPK1
    Poids moléculaire
    70 kDa/75 kDa
    ID gène
    8737
    UniProt
    Q13546
    Pathways
    Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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