SETD7 anticorps (AA 1-366)

N° du produit ABIN6147651

Détail du produit anti-SETD7 anticorps

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Épitope: AA 1-366

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD7 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SETD7 (NP_085151.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-SETD7 (ABIN6147651)

Yin, Jia, Miron, Long, Xu, Wei, Wu, Zhang, Li: "Setd7 and its contribution to Boron-induced bone regeneration in Boron-mesoporous bioactive glass scaffolds." dans: Acta biomaterialia, Vol. 73, pp. 522-530, (2018) (PubMed).

Détails sur SETD7

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Autre désignation: SETD7 (SETD7 Produits)

Synonymes: anticorps KMT7, anticorps SET7, anticorps SET7/9, anticorps SET9, anticorps set7, anticorps zgc:101860, anticorps zgc:92330, anticorps 1600028F23Rik, anticorps H3K4MT, anticorps Set7, anticorps Set7/9, anticorps mKIAA1717, anticorps SET domain containing lysine methyltransferase 7, anticorps SET domain containing (lysine methyltransferase) 7, anticorps SETD7, anticorps setd7, anticorps Setd7

Sujet: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.,SETD7,KMT7,SET7,SET7/9,SET9,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD7

Poids moléculaire: 40 kDa

ID gène: 80854

UniProt: Q8WTS6