SHARPIN anticorps (AA 1-170)

N° du produit ABIN6147733

Détail du produit anti-SHARPIN anticorps

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Épitope: AA 1-170

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHARPIN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRRLQLSADP ERPGRFRLEL LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT VEGQNGSKSN SPPALGPEAC PVSLPSPPEA STLKGPPPEA DLPRSPGNLT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SHARPIN (NP_112236.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SHARPIN

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Autre désignation: SHARPIN (SHARPIN Produits)

Synonymes: anticorps 0610041B22Rik, anticorps AW121341, anticorps RBCKL1, anticorps SIPL1, anticorps cpdm, anticorps Conneck1, anticorps SHANK-associated RH domain interacting protein, anticorps SHANK associated RH domain interactor, anticorps SHANK-associated RH domain interactor, anticorps Sharpin, anticorps SHARPIN

Sujet: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.,SHARPIN,SIPL1,sharpin,Cell Biology & Developmental Biology,Ubiquitin,SHARPIN

Poids moléculaire: 33 kDa/39 kDa

ID gène: 81858

UniProt: Q9H0F6