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MTR4 anticorps (AA 1-304)

SKIV2L2 Reactivité: Humain WB, IHC, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6147814
  • Antigène Voir toutes MTR4 (SKIV2L2) Anticorps
    MTR4 (SKIV2L2) (Superkiller Viralicidic Activity 2-Like 2 (SKIV2L2))
    Épitope
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-304
    Reactivité
    • 26
    • 15
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 26
    Lapin
    Clonalité
    • 26
    Polyclonal
    Conjugué
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTR4 est non-conjugé
    Application
    • 15
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Séquence
    MADAFGDELF SVFEGDSTTA AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSESTNNG KNKRDVDFEG TDEPIFGKKP RIEESITEDL SLADLMPRVK VQSVETVEGC THEVALPAEE DYLPLKPRVG KAAKEYPFIL DAFQREAIQC VDNNQSVLVS AHTSAGKTVC AEYAIALALR EKQRVIFTSP IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS EVMREVAWVI FDEIHYMRDS ERGVVWEETI ILLPDNVHYV FLSATIPNAR QFAEWICHLH KQPC
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human SKIV2L2 (NP_056175.3).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
    Commentaires

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    MTR4 (SKIV2L2) (Superkiller Viralicidic Activity 2-Like 2 (SKIV2L2))
    Autre désignation
    SKIV2L2 (SKIV2L2 Produits)
    Synonymes
    anticorps RGD1305984, anticorps zgc:63838, anticorps wu:fd11a05, anticorps SKIV2L2, anticorps skiv2l2, anticorps Dob1, anticorps KIAA0052, anticorps Mtr4, anticorps fSAP118, anticorps 2610528A15Rik, anticorps mKIAA0052, anticorps Ski2 like RNA helicase 2, anticorps superkiller viralicidic activity 2-like 2, anticorps superkiller viralicidic activity 2-like 2 (S. cerevisiae), anticorps Skiv2l2, anticorps skiv2l2, anticorps SKIV2L2, anticorps LOC100380870
    Sujet
    Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT and poly(A tail exosome targeting (PAXT. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex. Plays a role in DNA damage response.,SKIV2L2,Dob1,KIAA0052,Mtr4,fSAP118,Epigenetics & Nuclear Signaling,RNA Binding,SKIV2L2
    Poids moléculaire
    117 kDa
    ID gène
    23517
    UniProt
    P42285
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