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SQSTM1 anticorps (AA 1-440)

Name: SQSTM1 anticorps (AA 1-440)
Brand: antibodies-online
SKU: ABIN6148419
Price: 866.84 EUR
Availability: InStock

SQSTM1 Reactivité: Humain WB, IHC, IF, IP Hôte: Lapin Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using SQSTM1 antibody. (SQSTM1 anticorps (AA 1-440))

Confocal immunofluorescence analysis of U-2 OS cells using SQSTM1/p62 Polyclonal Antibody (ABIN6128552, ABIN6148419, ABIN6148425 and ABIN6223705) at dilution of 1:200. (SQSTM1 anticorps (AA 1-440))

Immunofluorescence analysis of U2OS cells using SQSTM1 antibody. (SQSTM1 anticorps (AA 1-440))

Immunohistochemistry of paraffin-embedded rat brain using SQSTM1 antibody. (SQSTM1 anticorps (AA 1-440))

IHC (p)

GPA promotes Nur77 to colocalization at mitochondria to induce autophagy. (SQSTM1 anticorps (AA 1-440))

Immunohistochemistry of paraffin-embedded rat stomach using SQSTM1/p62 Rabbit pAb (ABIN6128552, ABIN6148419, ABIN6148425 and ABIN6223705) at dilution of 1:100 (40x lens). (SQSTM1 anticorps (AA 1-440))

IHC

Confocal immunofluorescence analysis of Hela cells using SQSTM1/p62 Polyclonal Antibody (ABIN6128552, ABIN6148419, ABIN6148425 and ABIN6223705) at dilution of 1:200. (SQSTM1 anticorps (AA 1-440))

7 images

(1 reference)

N° du produit ABIN6148419

Fiche de données

Antigène Voir toutes SQSTM1 Anticorps

SQSTM1 (Sequestosome 1 (SQSTM1))
Épitope
17

15

11

9

8

7

7

5

5

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-440
Reactivité
140

58

54

18

4

4

4

4

3

2

2

2

1

1

1

1
Humain
Hôte
116

22

1

1
Lapin
Anticorps secondaires appropriés
Clonalité
114

26
Polyclonal
Conjugué
77

9

8

5

5

5

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp SQSTM1 est non-conjugé
Application
98

52

39

35

22

18

17

16

14

13

9

5

3

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Séquence

MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPL

Réactivité croisée

Humain, Souris, Rat

Attributs du produit

Polyclonal Antibodies

Immunogène

Recombinant fusion protein containing a sequence corresponding to amino acids 1-440 of human SQSTM1/p62 (NP_001135770.1).

Isotype

IgG

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Indications d'application

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Commentaires

HIGH QUALITY

Restrictions

For Research Use only
Format

Liquid

Buffer

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store at -20°C. Avoid freeze / thaw cycles.
Deng, Pan, Cheng, Liu, Zhang, Zhang, Xu: "Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD." dans: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1862, Issue 3, pp. 337-350, (2017) (PubMed).
Antigène

SQSTM1 (Sequestosome 1 (SQSTM1))

Autre désignation

SQSTM1 (SQSTM1 Produits)

Sujet

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.,SQSTM1,A170,DMRV,FTDALS3,NADGP,OSIL,PDB3,ZIP3,p60,p62,p62B,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Autophagy,Endocrine & Metabolism,Mitochondrial metabolism,Cardiovascular,Heart,Mitochondrial Control of Autophagy,SQSTM1

Poids moléculaire

38 kDa/47 kDa

ID gène

8878

UniProt

Q13501

Pathways

Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy