TANK anticorps (AA 1-119)

N° du produit ABIN6148843

Détail du produit anti-TANK anticorps

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Épitope: AA 1-119

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TANK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human TANK (NP_597841.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-TANK (ABIN6148843)

Qian, Fan, Liu, Wu, Zhang, Cui, Zhou, Hu, Wei, Chen, Li, Qian: "Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage." dans: Journal of virology, Vol. 91, Issue 16, (2017) (PubMed).

Détails sur TANK

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Autre désignation: TANK (TANK Produits)

Synonymes: anticorps I-TRAF, anticorps ITRAF, anticorps TRAF2, anticorps C86182, anticorps E430026L09Rik, anticorps zgc:153048, anticorps i-traf, anticorps tank, anticorps traf2, anticorps TRAF family member associated NFKB activator, anticorps TRAF family member-associated Nf-kappa B activator, anticorps TRAF family member-associated NFKB activator, anticorps TRAF family member associated NFKB activator L homeolog, anticorps TANK, anticorps Tank, anticorps tank, anticorps tank.L

Sujet: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.,TANK,I-TRAF,ITRAF,TRAF2,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,TNF,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,TANK

Poids moléculaire: 13 kDa/47 kDa

ID gène: 10010

UniProt: Q92844

Pathways: Signalisation p53, Signalisation TLR, Activation of Innate immune Response