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CARD11 anticorps (C-Term)
CARD11
Reactivité: Humain, Souris
WB, IHC (p), EIA
Hôte: Chèvre
Polyclonal
unconjugated
Détail du produit anti-CARD11 anticorps
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Antigène
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CARD11
(Caspase Recruitment Domain Family, Member 11 (CARD11))
Épitope
Tous les épitopes à travers CARD11 Anticorps.
C-Term
Reactivité
Toutes les réactivités sur CARD11 Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur CARD11 Anticorps
Chèvre
Clonalité
Toutes les clonalités sur CARD11 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers CARD11 Anticorps
Cet anticorp CARD11 est non-conjugé
Application
Tous les applications à travers CARD11 Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Séquence
C-QRKTIWVDED QL
Specificité
This antibody detects CARD11 / CARMA1 at C-term.
Réactivité croisée (Details)
Species reactivity (expected):MouseSpecies reactivity (tested):Human
Purification
Immunoaffinity chromatography
Immunogène
Synthetic peptide from C-term of human CARD11 Genename: CARD11
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Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Détails sur CARD11
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Antigène
CARD11
(Caspase Recruitment Domain Family, Member 11 (CARD11))
Autre désignation
CARD11 / CARMA1 (CARD11 Produits )
Synonymes
anticorps BENTA, anticorps BIMP3, anticorps CARMA1, anticorps PPBL, anticorps 0610008L17Rik, anticorps 2410011D02Rik, anticorps CARD11, anticorps LOC100232755, anticorps caspase recruitment domain family member 11, anticorps caspase recruitment domain family, member 11, anticorps caspase recruitment domain-containing protein 11, anticorps CARD11, anticorps Card11, anticorps LOC100550812, anticorps card11
Sujet
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11
ID gène
84433
NCBI Accession
NP_115791
UniProt
Q9BXL7
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , BCR Signaling
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