anticorps NIRF, anticorps RNF107, anticorps URF2, anticorps 2310065A22Rik, anticorps AI426270, anticorps AW214556, anticorps D130071B19Rik, anticorps Nirf, anticorps ubiquitin like with PHD and ring finger domains 2, anticorps ubiquitin-like, containing PHD and RING finger domains 2, anticorps ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog, anticorps UHRF2, anticorps Uhrf2, anticorps uhrf2.L
Sujet
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.,UHRF2,NIRF,RNF107,TDRD23,URF2,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Ubiquitin,UHRF2