XPC anticorps (AA 700-940)

N° du produit ABIN6150295

Détail du produit anti-XPC anticorps

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Épitope: AA 700-940

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Séquence: GEVPYKMVKG FSNRARKARL AEPQLREEND LGLFGYWQTE EYQPPVAVDG KVPRNEFGNV YLFLPSMMPI GCVQLNLPNL HRVARKLDID CVQAITGFDF HGGYSHPVTD GYIVCEEFKD VLLTAWENEQ AVIERKEKEK KEKRALGNWK LLAKGLLIRE RLKRRYGPKS EAAAPHTDAG GGLSSDEEEG TSSQAEAARI LAASWPQNRE DEEKQKLKGG PKKTKREKKA AASHLFPFEQ L

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 700-940 of human XPC (NP_004619.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IP,1:50 - 1:100

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-XPC (ABIN6150295)

Gu, Chang, Dai, Song, Zhao, Lei: "Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant." dans: Gene, Vol. 628, pp. 162-169, (2017) (PubMed).

Détails sur XPC

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Autre désignation: XPC (XPC Produits)

Synonymes: anticorps RAD4, anticorps XP3, anticorps XPCC, anticorps XPC complex subunit, DNA damage recognition and repair factor, anticorps xeroderma pigmentosum, complementation group C, anticorps XPC, anticorps Xpc

Sujet: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.,XPC,RAD4,XP3,XPCC,p125,Epigenetics & Nuclear Signaling,DNA Damage & Repair,XPC

Poids moléculaire: 15 kDa/101 kDa/105 kDa

ID gène: 7508

UniProt: Q01831

Pathways: Signalisation p53, Réparation de l'ADN