XRCC5 anticorps (AA 543-732)
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- Antigène Voir toutes XRCC5 Anticorps
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
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Épitope
- AA 543-732
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp XRCC5 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Séquence
- KKKDQVTAQE IFQDNHEDGP TAKKLKTEQG GAHFSVSSLA EGSVTSVGSV NPAENFRVLV KQKKASFEEA SNQLINHIEQ FLDTNETPYF MKSIDCIRAF REEAIKFSEE QRFNNFLKAL QEKVEIKQLN HFWEIVVQDG ITLITKEEAS GSSVTAEEAK KFLAPKDKPS GDTAAVFEEG GDVDDLLDMI
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
- Polyclonal Antibodies
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 543-732 of human Ku80 (NP_066964.1).
- Isotype
- IgG
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- Indications d'application
- WB,1:500 - 1:2000,IHC,1:100 - 1:200,IF,1:20 - 1:100,IP,1:50 - 1:200
- Commentaires
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." dans: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." dans: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
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Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." dans: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
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- Antigène
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
- Autre désignation
- XRCC5 (XRCC5 Produits)
- Synonymes
- anticorps AI314015, anticorps Ku80, anticorps Ku86, anticorps Kup80, anticorps KARP-1, anticorps KARP1, anticorps KU80, anticorps KUB2, anticorps NFIV, anticorps xrcc5-a, anticorps XRCC5, anticorps X-ray repair cross complementing 5, anticorps X-ray repair complementing defective repair in Chinese hamster cells 5, anticorps X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog, anticorps XRCC5, anticorps Xrcc5, anticorps xrcc5.L
- Sujet
- The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.,XRCC5,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RNA Binding,XRCC5
- Poids moléculaire
- 82 kDa
- ID gène
- 7520
- UniProt
- P13010
- Pathways
- Réparation de l'ADN
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