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Blood Group Lewis B anticorps

Reactivité: Humain, Cobaye, Porc IF, IHC (f), ISt Hôte: Souris Monoclonal 2-25LE unconjugated
N° du produit ABIN6153110
  • Antigène Tous les produits Blood Group Lewis B
    Blood Group Lewis B
    Reactivité
    Humain, Cobaye, Porc
    Hôte
    • 13
    Souris
    Clonalité
    • 13
    Monoclonal
    Conjugué
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Blood Group Lewis B est non-conjugé
    Application
    • 11
    • 8
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunostaining (ISt)
    Fonction
    Mouse Monoclonal anti-Lewis-B (2-25LE), Purified, BSA-free
    Attributs du produit
    The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Purification
    Purified
    Immunogène
    Mucin isolated from a human ovarian cyst fluid
    Clone
    2-25LE
    Isotype
    IgG1 kappa
  • Indications d'application
    Immunohistology formalin-fixed 0.5-1 μg/mL
    • Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
    • Immunofluorescence 0.5-1 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Commentaires

    Colon

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (no BSA, no azide)
    Agent conservateur
    Azide free
  • Antigène
    Blood Group Lewis B
    Autre désignation
    Lewis-B (Blood Group Lewis B Produits)
    Synonymes
    anticorps MUC5, anticorps TBM, anticorps leB, anticorps mucin 5AC, oligomeric mucus/gel-forming, anticorps MUC5AC
    Poids moléculaire
    45 kDa
    ID gène
    2525, 169238
    UniProt
    P21217
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