TSHR, A Chain anticorps (Biotin)
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- Antigène Tous les produits TSHR, A Chain
- TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
- Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TSHR, A Chain est conjugé à/à la Biotin
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
- Fonction
- Mouse Monoclonal anti-TSH Receptor, A chain (TSHRA/1402), Biotin Conjugate
- Attributs du produit
- Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- A-Chain protein|Recombinant human TSHR
- Clone
- TSHRA-1402
- Isotype
- IgG kappa
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- Indications d'application
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Immunohistology (formalin) 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA
- pH 9.0
- or 10 mM citrate buffer
- pH 6.0
- for 10-20 min followed by cooling at RT for 20 min
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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293T Cells. Thyroid gland
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
- Autre désignation
- TSH Receptor, A chain (TSHR, A Chain Produits)
- Sujet
- CHNG1, hTSHRI, LGR3, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, TSHR
- Poids moléculaire
- 62 kDa
- ID gène
- 7253, 160411
- UniProt
- P16473
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