FAT Atypical Cadherin 2 (FAT2) anticorps (CF®647)
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- Antigène Voir toutes FAT Atypical Cadherin 2 (FAT2) Anticorps
- FAT Atypical Cadherin 2 (FAT2)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- CF®647
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Application
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Fonction
- Mouse Monoclonal anti-Protocadherin-FAT2 (8C5), CF647 Conjugate
- Attributs du produit
- This antibody recognizes a protein of 480 kDa, which is identified as FAT2. The cadherins represent a family of Ca2 -dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ?-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Purified recombinant human FAT2 fusion protein
- Clone
- 8C5
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FAT2 Anticorps primaire
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- Indications d'application
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Immunohistology (formalin) 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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Esophagus, Cervix, Uterus, Tonsil or Cerebellum.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
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- Antigène
- FAT Atypical Cadherin 2 (FAT2)
- Autre désignation
- Protocadherin-FAT2 (FAT2 Produits)
- Synonymes
- anticorps EMI2, anticorps Fath2, anticorps Gm523, anticorps mKIAA0811, anticorps CDHF8, anticorps CDHR9, anticorps HFAT2, anticorps MEGF1, anticorps FAT atypical cadherin 2, anticorps Fat2, anticorps FAT2
- Poids moléculaire
- 480 kDa
- ID gène
- 2196, 591255
- UniProt
- Q9NYQ8
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