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Melanoma Marker anticorps (CF®405S)

Reactivité: Humain IHC, IF Hôte: Souris Monoclonal KBA-62 CF®405S
N° du produit ABIN6157139
  • Antigène Tous les produits Melanoma Marker
    Melanoma Marker
    Reactivité
    • 48
    • 10
    • 10
    Humain
    Hôte
    • 48
    Souris
    Clonalité
    • 48
    Monoclonal
    Conjugué
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Melanoma Marker est conjugé à/à la CF®405S
    Application
    • 29
    • 18
    • 18
    • 18
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Fonction
    Mouse Monoclonal anti-Melanoma Marker (KBA.62), CF405S Conjugate
    Attributs du produit
    KBA.62 is a novel anti-melanoma antibody. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, it reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. KBA.62 antibody is useful in identifying malignant melanomas. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, sarcomas, spindle cell carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immuno-reacts with antibody to S-100 protein and with KBA.62 antibody is, with rare exception, a melanoma. Anti-KBA.62 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micro-metastasis in sentinel lymph node. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogène
    Human KAL cells derived from lymph node metastasis of malignant melanoma
    Clone
    KBA-62
    Isotype
    IgG1 kappa
  • Indications d'application
    Immunohistology (formalin)
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
    • Immunofluorescence 0.5-1 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Commentaires

    SK-MEL-13 and SK-MEL-19 Melanoma cell lines, Melanomas

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Protect from light
  • Antigène
    Melanoma Marker
    Abstract
    Melanoma Marker Produits
    Sujet
    Human Melanoma Associated Antigen, KBA.62
    Poids moléculaire
    Multiple (140, 135 and 128 kDa and two weak bands of 88 and 73 kDa)
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