HAP1 anticorps (C-Term)
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- Antigène Voir toutes HAP1 Anticorps
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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Épitope
- C-Term
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Reactivité
- Souris, Rat
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HAP1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Séquence
- C-QDAHSKRQQK QK
- Specificité
- Recognizes Mouse Hap1
- Réactivité croisée (Details)
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Species reactivity (expected):Rat.
Species reactivity (tested):Mouse. - Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
- Immunogène
- Peptide with sequence from the C Terminus of the protein sequence according to NP_034534.1. Genename: Hap1
- Top Product
- Discover our top product HAP1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
- Autre désignation
- HAP1 (HAP1 Produits)
- Synonymes
- anticorps HAP2, anticorps HIP5, anticorps HLP, anticorps hHLP1, anticorps HAP1-A, anticorps HAP1-B, anticorps HAP-1, anticorps huntingtin associated protein 1, anticorps huntingtin-associated protein 1, anticorps HAP1, anticorps Hap1
- Sujet
- Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. HAP-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1
- ID gène
- 15114
- NCBI Accession
- NP_034534
- UniProt
- O35668
- Pathways
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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