FLI1 anticorps (AA 107-261) (Biotin)
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- Antigène Voir toutes FLI1 Anticorps
- FLI1 (Friend Leukemia Virus Integration 1 (FLI1))
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Épitope
- AA 107-261
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FLI1 est conjugé à/à la Biotin
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Application
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Fonction
- Mouse Monoclonal anti-FLI1 (FLI1/1312), Biotin Conjugate
- Attributs du produit
- This antibody recognizes a protein of 51 kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus.Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing s Sarcoma (EWS)/Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Recombinant fragment (aa 107-261) of human FLI1 protein (exact sequence is proprietary)
- Clone
- FLI1-1312
- Isotype
- IgG
- Top Product
- Discover our top product FLI1 Anticorps primaire
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- Indications d'application
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Western blotting 1-2 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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THP1 and Raji cells. Tonsil, Ewing s sarcoma (EWS) and Angiosarcoma
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- FLI1 (Friend Leukemia Virus Integration 1 (FLI1))
- Autre désignation
- FLI1 (FLI1 Produits)
- Synonymes
- anticorps EWSR2, anticorps SIC-1, anticorps FLI1, anticorps fli, anticorps Xfli, anticorps fli1, anticorps Xfli1, anticorps fli-1, anticorps Xfli-1, anticorps MGC121593, anticorps Fli-1, anticorps Sic1, anticorps cb855, anticorps wu:fc45b11, anticorps xlfli, anticorps Fli-1 proto-oncogene, ETS transcription factor, anticorps Fli-1 proto-oncogene, ETS transcription factor S homeolog, anticorps Friend leukemia integration 1, anticorps Fli-1 proto-oncogene, ETS transcription factor a, anticorps Fli-1 proto-oncogene, ETS transcription factor L homeolog, anticorps FLI1, anticorps Fli1, anticorps fli1.S, anticorps fli1, anticorps fli1a, anticorps fli1.L
- Poids moléculaire
- 51 kDa
- ID gène
- 2313, 504281
- UniProt
- Q01543
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