ANO1 anticorps (AA 2-101) (Biotin)
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- Antigène Voir toutes ANO1 Anticorps
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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Épitope
- AA 2-101
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ANO1 est conjugé à/à la Biotin
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Application
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Fonction
- Mouse Monoclonal anti-DOG-1 / TMEM16A (DG1/1485), Biotin Conjugate
- Attributs du produit
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4 % vs. 94.7 %. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
- Clone
- DG1-1485
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product ANO1 Anticorps primaire
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- Indications d'application
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Immunohistology (formalin) 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
- Autre désignation
- DOG-1 / TMEM16A (ANO1 Produits)
- Synonymes
- anticorps DOG1, anticorps ORAOV2, anticorps TAOS2, anticorps TMEM16A, anticorps Tmem16a, anticorps anoctamin 1, anticorps anoctamin 1, calcium activated chloride channel, anticorps Ano1, anticorps ANO1
- Sujet
- Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A
- Poids moléculaire
- ~114 kDa
- ID gène
- 55107, 503074
- UniProt
- Q5XXA6
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