beta-2 Microglobulin anticorps
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- Antigène Voir toutes beta-2 Microglobulin (B2M) Anticorps
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
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Reactivité
- Humain, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp beta-2 Microglobulin est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Fonction
- Mouse Monoclonal anti-Beta-2 Microglobulin (B2M) (B2M/961), Purified, BSA-free
- Attributs du produit
- This antibody recognizes a protein of 12 kDa, identified as β2-microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an i± heavy chain that contains three subdomains (i±1, i±2, i±3) and a non-covalent associating light chain, known as i²-2-Microglobulin. i²-2-Microglobulin associates with the i±3 subdomain of the i± heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The i±1 and i±2 domains of the i± heavy chain form the peptide antigen-binding cleft. Mutations in the i²-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Purification
- Purified
- Immunogène
- Full length recombinant human B2M protein
- Clone
- B2M-961
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product B2M Anticorps primaire
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- Indications d'application
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Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Cervix, Endometrial, Kidney or Colon.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS (no BSA, no azide)
- Agent conservateur
- Azide free
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- Antigène
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
- Autre désignation
- Beta-2 Microglobulin (B2M) (B2M Produits)
- Synonymes
- anticorps Ly-m11, anticorps beta2-m, anticorps beta2m, anticorps bwm, anticorps wu:fa94c05, anticorps wu:fb10a09, anticorps b2m-W01, anticorps b2m-W03, anticorps b2m-Z01, anticorps b2m-Z02, anticorps b2m-Z03, anticorps B2M, anticorps b2m, anticorps B2MG, anticorps wu:fb66f11, anticorps wu:fj01f08, anticorps zgc:64161, anticorps b-2-m, anticorps beta-2-microglobulin, anticorps beta-2 microglobulin, anticorps beta-2-microglobulin S homeolog, anticorps beta-2-microglobulin, like, anticorps B2M, anticorps B2m, anticorps b2m, anticorps b2m.S, anticorps b2ml
- Sujet
- B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p
- Poids moléculaire
- 12 kDa
- ID gène
- 567, 534255
- UniProt
- P61769
- Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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