MAML3 anticorps (CF®405S)
-
- Antigène Voir toutes MAML3 Anticorps
- MAML3 (Mastermind-Like 3 (MAML3))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp MAML3 est conjugé à/à la CF®405S
-
Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunostaining (ISt)
- Fonction
- Mouse Monoclonal anti-MAML3 (MAML3/1303), CF405S Conjugate
- Attributs du produit
- MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J?, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Recombinant human full-length MAML3 protein
- Clone
- MAML3-1303
- Isotype
- IgG1
- Top Product
- Discover our top product MAML3 Anticorps primaire
-
-
- Indications d'application
-
Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA pH 9.0 for 10-20 min followed by cooling at RT for 20 min
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
-
MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
-
- Antigène
- MAML3 (Mastermind-Like 3 (MAML3))
- Autre désignation
- MAML3 (MAML3 Produits)
- Synonymes
- anticorps AV234550, anticorps BC049812, anticorps Mam-2, anticorps mKIAA1816, anticorps Glrp1, anticorps CAGH3, anticorps ERDA3, anticorps GDN, anticorps MAM-2, anticorps MAM2, anticorps TNRC3, anticorps mastermind like 3 (Drosophila), anticorps mastermind-like transcriptional coactivator 3, anticorps mastermind like transcriptional coactivator 3, anticorps Maml3, anticorps MAML3
- Sujet
- CAGH3, ERDA3, GDN, MAML3, Mastermind-like protein 3, TNRC3
- Poids moléculaire
- 150-170 kDa
- ID gène
- 55534
-